The Guzmán López brothers began their narcotics trafficking careers early by inheriting relationships from their deceased brother, Edgar Guzmán López. Following Edgar’s death, Ovidio and Joaquín inherited a great deal of the narcotics proceeds and began investing large amounts of the cash into the purchasing of marijuana in Mexico and cocaine in Colombia. They also began purchasing large amounts of ephedrine from Argentina and arranged for the smuggling of the product into Mexico as they began to experiment with methamphetamine production.
The Guzmán López brothers are currently overseeing approximately eleven methamphetamine labs in the state of Sinaloa producing an estimated 3,000 - 5,000 pounds of methamphetamine per month. The methamphetamine is sold wholesale to other Sinaloa members and to U.S.- and Canadian-based distributors. Other information indicates that Ovidio Guzmán López has ordered the murders of informants, a drug trafficker, and a popular Mexican singer who had refused to sing at his wedding.
On April 2, 2018, both of the Guzmán López brothers were indicted by a Federal Grand Jury in the District of Columbia and charged with one count of 21 USC Sections 959(a), 960 and 963 (conspiracy to distribute more than 5 kilograms of cocaine, 500 grams of methamphetamine, and 1,000 kilograms of marijuana).